Must know
Focal epileptiform discharge, sharp wave - Example
A sharp transient is characterized as epileptiform if it meets at least 4 out of 6 criteria proposed by the International Federation of Clinical Neurophysiology (IFCN) to define interictal epileptiform discharges: (1) sharp/spiky, (2) waveform width different from the ongoing background activity, (3) asymmetric, (4) followed by an aftergoing slow wave, (5) disruption of the background, and (6) physiological field. Morphologically, an epileptiform discharge is classified as a sharp wave if its duration falls within the range of 70 to 200 milliseconds.
Focal epileptiform discharge, spike - Example
A sharp transient is characterized as epileptiform if it meets at least 4 out of 6 criteria proposed by the International Federation of Clinical Neurophysiology (IFCN) to define interictal epileptiform discharges: (1) sharp/spiky, (2) waveform width different from the ongoing background activity, (3) asymmetric, (4) followed by an aftergoing slow wave, (5) disruption of the background, and (6) physiological field. Morphologically, an epileptiform discharge is classified as a spike if its duration falls within the range of 20 to 70 milliseconds.
Focal epileptiform discharges, polyspikes - Example
A sharp transient is characterized as epileptiform if it meets at least 4 out of 6 criteria proposed by the International Federation of Clinical Neurophysiology (IFCN) to define interictal epileptiform discharges: (1) spiky, (2) waveform width different from the ongoing background activity, (3) asymmetric, (4) followed by an aftergoing slow wave, (5) disruption of the background, and (6) physiological field with a bifrontal/midline predominance. Morphologically, an epileptiform discharge is classified as polyspikes if it consists of a sequence of more than two consecutive spikes.
Focal seizure - Example
Focal seizures, on EEG, are defined as (a) epileptiform discharges averaging >2.5 Hz for ≥10 seconds, or (b) any pattern with definite evolution lasting ≥10 seconds.
Generalized epileptiform discharges, 3 Hz - Example
Generalized epileptiform discharges, 3 Hz, are characterized by a burst of 3 Hz bilaterally synchronous (generalized) sharp transients that meet the criteria proposed by the International Federation of Clinical Neurophysiology (IFCN) to define interictal epileptiform discharges.
Generalized epileptiform discharges, 3 Hz, polyspike-wave - Example
Generalized epileptiform discharges, 3 Hz, polyspike-wave are characterized by a burst of 3 Hz bilaterally synchronous (generalized) sharp transients that meet at least 4 out of 6 criteria proposed by the International Federation of Clinical Neurophysiology (IFCN) to define interictal epileptiform discharges: (1) sharp/spiky, (2) waveform width different from the ongoing background activity, (3) asymmetric, (4) followed by an aftergoing slow wave, (5) disruption of the background, and (6) physiological field. Morphologically, an epileptiform discharge is classified as a polyspike-wave if it consists of a short duration spike (20 to 70 milliseconds) followed by an aftergoing slow wave. Additionally, these spike-wave complexes consist of a sequence of more than two consecutive spikes per complex, meeting the criteria for polyspikes.
Generalized epileptiform discharges, ≤2.5 Hz - Example
Generalized epileptiform discharges, ≤2.5 Hz are characterized by a burst of ≤2.5 Hz rhythmic generalized sharp transients that meet at least 4 out of 6 criteria proposed by the International Federation of Clinical Neurophysiology (IFCN) to define interictal epileptiform discharges. This interictal pattern of generalized slow (≤2.5 Hz) epileptiform (spike-wave) discharges is typically seen in patients with Lennox-Gastaut syndrome (LGS).
Videos
- EEG Talk Curriculum - Spike Operational Criteria (Part 1)
- EEG Talk Curriculum - Spike Operational Criteria (Part 2)
- EEG Talk - Episode 2: Generalized 3 Hz SW
- EEG Talk - Episode 3: Left Temporal Epileptiform Discharges
- EEG Talk - Episode 5: Temporal Seizures
- EEG Talk - Episode 6: Triphasic Waves
- EEG Talk - Episode 8: Spikes That Reverse Nowhere
- Roadmap to EEGs: Interictal Epileptiform Discharges
- Roadmap to EEGs: Focal Seizures Part 1
- Roadmap to EEG's: Focal Seizures Part 2
Reference Articles
- Amin U, Nascimento FA, Karakis I, Schomer D, Benbadis SR. Normal variants and artifacts: Importance in EEG interpretation. Epileptic Disord. 2023 Oct;25(5):591-648. PMID 36938895
- Bourgeois BF, Douglass LM, Sankar R. Lennox-Gastaut syndrome: a consensus approach to differential diagnosis. Epilepsia. 2014 Sep;55 Suppl 4:4-9. PMID 25284032
- Halász P, Janszky J, Barcs G, Szucs A. Generalised paroxysmal fast activity (GPFA) is not always a sign of malignant epileptic encephalopathy. Seizure. 2004 Jun;13(4):270-6. PMID 15121138
- Hirsch E, French J, Scheffer IE, et al. ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022 Jun;63(6):1475-1499. PMID 35503716
- Kane N, Acharya J, Benickzy S, et al. A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. Revision 2017. Clin Neurophysiol Pract. 2017 Aug 4;2:170-185. PMID 30214992
- Ko A, Kong J, Samadov F, et al. Significance of polyspikes on electroencephalography in children with focal epilepsy. Ann Child Neurol. 2022;30(2):45-52. Link
- Kural MA, Duez L, Sejer Hansen V, et al. Criteria for defining interictal epileptiform discharges in EEG: A clinical validation study. Neurology. 2020 May 19;94(20):e2139-e2147. PMID 32321764
- Leitinger M, Beniczky S, Rohracher A, et al. Salzburg Consensus Criteria for Non-Convulsive Status Epilepticus--approach to clinical application. Epilepsy Behav. 2015 Aug;49:158-63. PMID 26092326
- Nascimento FA, Beniczky S. Teaching the 6 criteria of the International Federation of Clinical Neurophysiology for defining interictal epileptiform discharges on EEG using a visual graphic. Neurology Education. 2023;2(2):e200073. PMID 39449781
- Nascimento FA, Thiele EA, Weber DJ. Diagnosing Lennox-Gastaut syndrome in an adult and its direct impact in epilepsy care. Epileptic Disord. 2022 Aug 1;24(4):729-732. PMID 35770769